Article
Host species-specific mutations in the thumb domain of the 3Dpol polymerase are required for efficient replication of human hepatitis A virus in mice.
PLoS pathogens - 1 May 2026
Misumi Ichiro, Shirasaki Takayoshi, Xie Ling, Yonish Bryan, González-López Olga, Hirai-Yuki Asuka, Chen Xian, Li You, Whitmire Jason K, Lemon Stanley M
Abstract excerpt
Hepatitis A virus (HAV) is a globally important cause of enterically-transmitted hepatitis. It is one of 9 distinct Hepatovirus species in the Picornaviridae, among which phylogenetic reconstructions suggest multiple past host species jumps. HAV readily infects mice with defective type I interferon responses, suggesting the major barrier preventing human HAV from replicating in a rodent host is an inability to...
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