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Article

IRF3-mediated pathogenicity in a murine model of human hepatitis A

30 Sept 2021

Abstract excerpt

HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved the role of IRF3-mediated transcription versus the non-transcriptional, pro-apoptotic activity of ubiquitylated IRF3. Here, we...

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PMID: 34591933
DOI: 10.1371/journal.ppat.1009960

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