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Article

Impact of critical-site mutations in the free fatty acid receptor 4 on the allosteric kinetics of endogenous fatty acid-receptor interactions.

Analytica chimica acta - 15 Jul 2026

Song Qingwei, Lu Dingqiang, Feng Chunlei, Pang Guangchang

Abstract excerpt

BACKGROUND: Free Fatty Acid Receptor 4 (FFAR4/GPR120) is a lipid-sensing GPCR, yet quantitative evidence linking binding-pocket residues to endogenous fatty-acid selectivity and coupling behavior remains limited. In particular, how Arg99, Trp198 and Trp207 cooperatively shape ligand-class dependence (saturated vs unsaturated; short-vs long-chain) has not been systematically quantified using a unified experimental...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42108048
DOI: 10.1016/j.aca.2026.345478

Genes

FFAR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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