Reduced IL-10 in the early postnatal period contributes to pro-inflammatory phenotype and autism-like behavior in offspring mice induced by maternal hypothyroidism during pregnancy.

Abstract excerpt

OBJECTIVE: To investigate the dynamic changes of five key cytokines in the prefrontal cortex of offspring from maternal hypothyroidism at different developmental time points and further identify potentially critical cytokines based on the magnitude and timing of their alterations. METHODS: Pregnant C57BL/6J mice were rendered hypothyroid with 0.2 g/L methimazole in drinking water from gestational day 9 to...

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