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Article

Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both sexes.

Frontiers in endocrinology - 1 Jan 2024

González-Madrid Enrique, Rangel-Ramírez Ma Andreina, Opazo María C, Méndez Luis, Bohmwald Karen, Bueno Susan M, González Pablo A, Kalergis Alexis M, Riedel Claudia A

Abstract excerpt

Background: The prevalence of autism spectrum disorder (ASD) has significantly risen in the past three decades, prompting researchers to explore the potential contributions of environmental factors during pregnancy to ASD development. One such factor of interest is gestational hypothyroxinemia (HTX), a frequent condition in pregnancy associated with cognitive impairments in the offspring. While retrospective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38752179
DOI: 10.3389/fendo.2024.1381180
PMCID: PMC11094302

Genes

HOMER1
NLGN3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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