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Article

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring.

International journal of molecular sciences - 8 Jun 2020

Cieślik Magdalena, Gąssowska-Dobrowolska Magdalena, Jęśko Henryk, Czapski Grzegorz A, Wilkaniec Anna, Zawadzka Aleksandra, Dominiak Agnieszka, Polowy Rafał, Filipkowski Robert K, Boguszewski Paweł M, Gewartowska Magdalena, Frontczak-Baniewicz Małgorzata, Sun Grace Y, Beversdorf David Q, Adamczyk Agata

Abstract excerpt

Maternal immune activation (MIA), induced by infection during pregnancy, is an important risk factor for neuro-developmental disorders, such as autism. Abnormal maternal cytokine signaling may affect fetal brain development and contribute to neurobiological and behavioral changes in the offspring. Here, we examined the effect of lipopolysaccharide-induced MIA on neuro-inflammatory changes, as well as synaptic...

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Identifiers

PMID: 32521803
DOI: 10.3390/ijms21114097
PMCID: PMC7312084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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