Article
(R)-ketamine attenuates neurodevelopmental disease-related phenotypes in a mouse model of maternal immune activation.
European archives of psychiatry and clinical neuroscience - 1 Oct 2023
de Oliveira Elifrances Galdino, de Lima Diógenes Afonso, da Silva Júnior José Carlos, de Souza Barbosa Mayara Victória, de Andrade Silva Severina Cassia, de Santana Jonata Henrique, Dos Santos Junior Osmar Henrique, Lira Eduardo Carvalho, Lagranha Claudia Jacques, Duarte Filipe Silveira, Gomes Dayane Aparecida
Abstract excerpt
Infections during pregnancy are associated with an increased risk of neuropsychiatric disorders with developmental etiologies, such as schizophrenia and autism spectrum disorders (ASD). Studies have shown that the animal model of maternal immune activation (MIA) reproduces a wide range of phenotypes relevant to the study of neurodevelopmental disorders. Emerging evidence shows that (R)-ketamine attenuates...
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