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Article

Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder.

Translational psychiatry - 3 Aug 2022

Hesam-Shariati Sonia, Overs Bronwyn J, Roberts Gloria, Toma Claudio, Watkeys Oliver J, Green Melissa J, Pierce Kerrie D, Edenberg Howard J, Wilcox Holly C, Stapp Emma K, McInnis Melvin G, Hulvershorn Leslie A, Nurnberger John I, Schofield Peter R, Mitchell Philip B, Fullerton Janice M

Abstract excerpt

Environmental factors contribute to risk of bipolar disorder (BD), but how environmental factors impact the development of psychopathology within the context of elevated genetic risk is unknown. We herein sought to identify epigenetic signatures operating in the context of polygenic risk for BD in young people at high familial risk (HR) of BD. Peripheral blood-derived DNA was assayed using Illumina PsychArray,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35922419
DOI: 10.1038/s41398-022-02079-6
PMCID: PMC9349272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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