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Rapid Naked-Eye Tracking of On-Cell Phenotype Based on Dual-Aptamer-Weaved Cascade Assembly of Nanostructures.

Analytical chemistry - 17 Aug 2021

Shi Hai, Wang Mengjiao, Gong Youjing, Huang Yue, Ning Limin, Xiang Yang, Yin Yongmei, Li Genxi

Abstract excerpt

Phenotypic plasticity is an emerging paradigm for providing biological and clinical insights into cancer initiation, progression, and resistance to therapy. However, it is a great challenge to track phenotypic information on live cells with high levels of sensitivity, specificity, and simplicity, when a specific cancer-cell subset is being targeted. In this work, we have successfully achieved cascade assembly of...

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PMID: 34347435
DOI: 10.1021/acs.analchem.1c01668

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