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Article

Circulating Inflammatory Proteins and Fuchs Endothelial Corneal Dystrophy: A Mendelian Randomization and Bioinformatics-Based Investigation.

Translational vision science & technology - 1 May 2026

Wu Dan, Li Gang, Cui Xinhan, Zhang Jing

Abstract excerpt

Purpose: Fuchs endothelial corneal dystrophy (FECD) is an age-related ocular disorder characterized by gradual loss of corneal endothelial cells, with growing evidence implicating chronic inflammation in its pathogenesis. This study aims to investigate causal relationships between circulating inflammatory proteins (IPs) and FECD. Methods: We performed bidirectional two-sample Mendelian randomization (MR) analysis...

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Source

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Identifiers

PMID: 42101419
DOI: 10.1167/tvst.15.5.6
PMCID: PMC13175216

Genes

TNFRSF11B
MIP
NRTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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