Causal association between 91 circulating inflammatory proteins and primary open-angle glaucoma: a bidirectional Mendelian randomization study.

Abstract excerpt

BACKGROUND: Glaucoma, especially primary open-angle glaucoma (POAG), is a leading cause of irreversible vision loss. While elevated intraocular pressure is a major risk factor, the pathogenesis of POAG also involves genetics, oxidative stress, abnormal hemodynamics, and inflammatory factors. The role of systemic inflammation in POAG remains a subject of debate. This study aimed to investigate the causal...

Topics

• Humans
• Glaucoma, Open-Angle
• Mendelian Randomization Analysis
• Genome-Wide Association Study
• Inflammation
• Polymorphism, Single Nucleotide