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Article

Association of Polygenic Risk Scores With Aortic Valve Calcium: The Multi-Ethnic Study of Atherosclerosis.

Journal of the American Heart Association - 19 May 2026

Whelton Seamus P, Yao Jie, Clish Clary, Wood Alexis C, Taylor Kent D, Blaha Michael J, Budoff Matthew, Marrero Natalie, Thanassoulis George, Post Wendy S, Guo Xiuqing, Rotter Jerome I

Abstract excerpt

BACKGROUND: Aortic valve calcification (AVC) is the primary process leading to aortic stenosis. We examined whether polygenic risk scores (PRS) are associated with AVC beyond traditional atherosclerotic cardiovascular disease risk factors. METHODS: We included 6812 participants in MESA (Multi-Ethnic Study of Atherosclerosis) with computed tomography-measured AVC at Visit 1. Using previously published PRS we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42089167
DOI: 10.1161/JAHA.124.040064
PMCID: PMC13279466

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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