Article
Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis.
Molecular cancer research : MCR - 1 Nov 2018
Regan Anderson Tarah M, Ma Shihong, Perez Kerkvliet Carlos, Peng Yan, Helle Taylor M, Krutilina Raisa I, Raj Ganesh V, Cidlowski John A, Ostrander Julie H, Schwertfeger Kathryn L, Seagroves Tiffany N, Lange Carol A
Abstract excerpt
The metastatic cascade is a complex process that requires cancer cells to survive despite conditions of high physiologic stress. Previously, cooperation between the glucocorticoid receptor (GR) and hypoxia-inducible factors (HIF) was reported as a point of convergence for host and cellular stress signaling. These studies indicated p38 MAPK-dependent phosphorylation of GR on Ser134 and subsequent...
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