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Article

The Molecular Landscape of CASTLE: A Rare Thymus-like Head and Neck Cancer.

International journal of molecular sciences - 14 Apr 2026

Cho William C, Yu Allen C S, Cheuk Wah, Yim Aldrin K Y, Chow James C H, Chan John K C, Cheung Ka M

Abstract excerpt

Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignancy arising in the thyroid or neck, with an uncertain cellular origin that complicates both diagnosis and treatment. To better understand its molecular underpinnings and identify potential therapeutic avenues, we conducted integrated whole-exome and transcriptome sequencing on six CASTLE and six thymic carcinoma samples. Whole-exome...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42074143
DOI: 10.3390/ijms27083501
PMCID: PMC13116657

Genes

BCL9L
BRAF
CFAP46
DNAH6
TRHDE
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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