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Article

KRAS, EGFR, PDGFR-α, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE).

Diagnostic pathology - 16 Jun 2014

Veits Lothar, Schupfner Rupert, Hufnagel Petra, Penzel Roland, Freitag Jens, Ströbel Philipp, Kern Michael A, Schröder Sören, Neuhold Nikolaus, Schmid Kurt W, Schirmacher Peter, Hartmann Arndt, Rieker Ralf J

Abstract excerpt

BACKGROUND: CASTLE (Carcinoma showing thymus-like elements) is a rare malignant neoplasm of the thyroid resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus with different biological behaviour and a better prognosis than anaplastic carcinoma of the thyroid. METHODS: We retrospectively investigated 6 cases of this very rare neoplasm in order to investigate the mutational status of KRAS,...

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Identifiers

PMID: 24934485
DOI: 10.1186/1746-1596-9-116
PMCID: PMC4078982

Genes

EGFR
KIT
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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