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Article

The Mediating Role of Immune Cells in the Genetically Predicted Relationship between Gut Microbiota and Puerperal Sepsis: A Mendelian Randomization Study.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Chai Yihui, Gu Chunsong, Fan Zhiliang, Li Qian, Liu Chunyan, Niu Jianjun, Li Jun, Pu Xiang

Abstract excerpt

INTRODUCTION: The causal relationship between gut microbiota and puerperal sepsis (PS) remains unclear, and there is a lack of in-depth research regarding the potential mediating role of immune cells in this context. OBJECTIVE: This study aims to investigate the causal relationship between gut microbiota and PS using Mendelian randomization (MR) analysis and to assess the mediating effects of immune cells on the...

Read the complete abstract on PubMed

Topics

Humans
Gastrointestinal Microbiome
Female
Mendelian Randomization Analysis
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sepsis

Puerperal Infection

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41582389
DOI: 10.2174/0118715303415101251129044507
PMCID: PMC13531649

Genes

CD27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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