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Article

An antimorphic mutant of Brh2 resulting from a conservative amino acid change within the BRC element.

DNA repair - 1 May 2026

Sutherland Jeanette H, Valdez Gary E Xavier, Holloman William K

Abstract excerpt

Brh2, the streamlined BRCA2 family protein from Ustilago maydis, directs homologous recombination by modulating Rad51 filament dynamics through a single BRC element. Here, we describe an unusual antimorphic mutation within the BRC β-hairpin of Brh2, in which the pivotal phenylalanine residue in the sequence mimicking the Rad51 polymerization motif is replaced by methionine. This methionine-for-phenylalanine...

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Source

Identifiers

PMID: 42070350
DOI: 10.1016/j.dnarep.2026.103936

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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