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Article

Approaches to Understanding the Mediator Function of Brh2 in Ustilago maydis.

Methods in enzymology - 1 Jan 2018

Zhou Qingwen, Holloman William K, Kojic Milorad

Abstract excerpt

Primary components of the homologous recombination pathway in eukaryotes include Rad51 whose function is to search for DNA sequence homology and promote strand exchange, its mediator BRCA2, and Dss1, a key regulator of BRCA2. We seek to understand the role of BRCA2 in governing the activity of Rad51 and to learn how BRCA2 function is regulated by Dss1. We use the microbe Ustilago maydis as a model system for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29458772
DOI: 10.1016/bs.mie.2017.11.019

Genes

BRCA2

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Approaches to Understanding the Mediator Function of Brh2 in Ustilago maydis.PMID 29458772Read ↗

Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis.Semantic proximity Read ↗

The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis.Semantic proximity Read ↗

Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres.Semantic proximity Read ↗

Compensatory role for Rad52 during recombinational repair in Ustilago maydis.Semantic proximity Read ↗

An antimorphic mutant of Brh2 resulting from a conservative amino acid change within the BRC element.Semantic proximity Read ↗

Rec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydis.Semantic proximity Read ↗

Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster.Semantic proximity Read ↗

Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis.Semantic proximity Read ↗

Characterization of the interaction between the Saccharomyces cerevisiae Rad51 recombinase and the DNA translocase Rdh54.Semantic proximity Read ↗

Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis.Semantic proximity Read ↗

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.Semantic proximity Read ↗

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics.Semantic proximity Read ↗

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