Article
Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Mar 2017
Wang Hong, Hua Mingqiang, Wang Shukang, Yu Jie, Chen Chen, Zhao Xueyun, Zhang Chen, Zhong Chaoqin, Wang Ruiqing, He Na, Hou Ming, Ma Daoxin
Abstract excerpt
BACKGROUND: Though the pathogenesis of AML is still unknown, accumulating evidence revealed that immune response plays a vital part in it. NLRP3 inflammasome as a component of immune system has been found related to several cancers. The single nucleotide polymorphisms (SNPs) of NLRP3 inflammasome genes may be related to pathogenesis and prognosis of AML. METHODS AND RESULTS: We determined polymorphisms of NLRP3...
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