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Article

Sarcopenia and immune-mediated inflammatory diseases: Evaluating causality and exploring therapeutic targets for sarcopenia through Mendelian randomization.

International immunopharmacology - 10 Jan 2025

Wang Qijun, Zhao Xuan, Wang Shuaikang, Lu Shibao

Abstract excerpt

BACKGROUND: An increasing body of evidence has revealed the association between immune-mediated inflammatory diseases (IMIDs) and sarcopenia. However, a genetically direct causality between IMIDs and sarcopenia remains elusive. METHODS: To investigate the relationship between IMIDs and sarcopenia-related traits and identify potential therapeutic targets, a Mendelian randomization (MR) was performed. We collected...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Hand Strength
Inflammation
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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PMID: 39591827
DOI: 10.1016/j.intimp.2024.113687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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