Article
Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM.
Cancer discovery - 6 Oct 2025
Pearlman Alexander H, Wang Yuxuan, Kalluri Anita, Parker Megan, Cohen Joshua D, Dudley Jonathan, Rincon-Torroella Jordina, Xia Yuanxuan, Gensler Ryan, Alfonzo Horowitz Melanie, Theodore John N, Dobbyn Lisa, Popoli Maria, Ptak Janine, Silliman Natalie, Judge Kathy, Calabresi Peter A, Groves Mari, Jackson Christopher M, Jackson Eric M, Jallo George I, Lim Michael, Luciano Mark, Mukherjee Debraj, Naidoo Jarushka, Rozati Sima, Sterling Cole H, Weingart Jon, Koschmann Carl, Mansouri Alireza, Glantz Michael, Kamson David, Schreck Karisa C, Pardo Carlos A, Holdhoff Matthias, Konig Maximilian F, Paul Suman, Kinzler Kenneth W, Papadopoulos Nickolas, Vogelstein Bert, Douville Christopher, Bettegowda Chetan
Abstract excerpt
Patients with radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an invasive and dangerous procedure. In this study, we present a new workflow termed "CSF-BAM" that simultaneously identifies B-cell or T-cell receptor sequences, aneuploidy, and mutations using...
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