Article
Noninvasive detection of brain gliomas using plasma cell-free DNA 5-hydroxymethylcytosine sequencing.
International journal of cancer - 15 Apr 2023
Zhang Shuxin, Zhang Jun, Hu Xinlei, Yin Senlin, Yuan Yunbo, Xia Lin, Cao Feng, Yan Xiaoqin, Yan Ziyue, Mao Qing, Xie Dan, Liu Yanhui
Abstract excerpt
Liquid biopsy techniques based on deep sequencing of plasma cell-free DNA (cfDNA) could detect the low-frequency somatic mutations and provide an accurate diagnosis for many cancers. However, for brain gliomas, reliable performance of these techniques currently requires obtaining cfDNA from patients' cerebral spinal fluid, which is cumbersome and risky. Here we report a liquid biopsy method based on sequencing of...
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