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Article

Genetic variability in the leptin-melanocortin pathway and its role in weight loss.

Molecular metabolism - 1 Jun 2026

Santos-Pereira Mariana, Guimarães Marta, Monteiro Mariana P, Pereira Sofia S, Azevedo Luísa

Abstract excerpt

Obesity is a multifactorial disease characterized by an excessive and abnormal accumulation of body fat that results from both genetic and environmental factors. In this review, we revisited the literature on the variability of obesity-associated genes and their impact on the effectiveness of obesity treatment interventions. Individuals harboring variants of these genes were found to have either better or worse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42061509
DOI: 10.1016/j.molmet.2026.102377
PMCID: PMC13196459

Genes

BDNF
GHRL
GHSR
LEPR
MC4R
NPY
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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