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Article

The expanding landscape of genetic causes of obesity.

Pediatric research - 1 Mar 2025

Semenova Ekaterina, Guo Alex, Liang Harry, Hernandez Cindy J, John Ella B, Thaker Vidhu V

Abstract excerpt

Obesity and weight regulation disorders are determined by the combined effects of genetics and environment. Polygenic obesity results from the combination of common variants in several genes which predisposes the individual to obesity and its related complications. In contrast, monogenic obesity results from changes in single genes, especially those in leptin-melanocortin pathway, and presents with early onset...

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Identifiers

PMID: 39690244
DOI: 10.1038/s41390-024-03780-6
PMCID: PMC12242282

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