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Article

Genetic architecture of obesity and advances in precision pharmacotherapy: a comprehensive review.

Acta biochimica Polonica - 1 Jan 2026

Kavaja Floren, Liehr Thomas, Temaj Gazmend

Abstract excerpt

Obesity, a global health catastrophe, arises from complex interactions between environmental factors and genetic predispositions. This review summarizes the current state of knowledge on the genetic basis of obesity and contrasts rare monogenic forms caused by mutations in a single gene with common polygenic forms caused by hundreds of genetic variants with small effects. We highlight important genes in...

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Identifiers

PMID: 42022796
DOI: 10.3389/abp.2026.15484
PMCID: PMC13096749

Genes

FTO
LEP
MC4R
POMC
SEC16B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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