Article
The genetics of obesity: aetiology, prevention and therapy.
Nature metabolism - 1 Apr 2026
Bonnefond Amélie, Bruner Winter S, Grant Struan F A, Morandi Anita, Froguel Philippe
Abstract excerpt
Obesity is a complex, multifactorial condition with a strong genetic basis, encompassing monogenic, oligogenic and polygenic contributions. More than 1 billion people worldwide have obesity, including 150 million children. Since the discovery of leptin, over 85 monogenic forms have been identified, characterized by early-onset obesity with impaired appetite regulation, usually associated with neurodevelopmental...
Topics
- Humans
- Obesity
- Genome-Wide Association Study
- Precision Medicine
- Genetic Predisposition to Disease
- Receptor, Melanocortin, Type 4
- Leptin