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Identification of Alzheimer's disease subtypes and biomarkers from human multi-omics data using subspace merging algorithm.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2026

Song Ziyan, Huang Xiaoqing, Jannu Asha Jacob, Johnson Travis S, Zhang Jie, Huang Kun

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS: We applied a subspace-merging algorithm to integrate multi-omics data from brain tissues of three large AD cohorts and identify data-driven AD subtypes....

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PMID: 42056682
DOI: 10.1002/alz.71292
PMCID: PMC13128347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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