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Identify Alzheimer’s disease subtypes and markers from multi-omic data of human brain and blood with a subspace merging algorithm

2025-05-07

Abstract excerpt

<h4>Summary</h4> Identifying Alzheimer’s disease (AD) subtypes is essential for AD diagnosis and treatment. We integrated multiomics data from brain tissues of the ROSMAP and MSBB studies using a subspace merging algorithm and identified two AD patient clusters with notable cognitive and AD pathology differences. Analysis of differentially expressed genes (DEGs) in brain and blood samples pinpointed the LDLR gene...

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Literature Corpus work
3bb38148-2b62-5133-b012-557c7be339bf
DOI
10.1101/2025.04.30.651565
Open publication

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Identify Alzheimer’s disease subtypes and markers from multi-omic data of human brain and blood with a subspace merging algorithmDOI 10.1101/2025.04.30.651565
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