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Article

A functional SNP rs12718466 in APOA1 promoter modulates gene expression via interaction with SOX7.

The Journal of biological chemistry - 1 Jun 2026

Aita Yuichi, Takeuchi Yoshinori, Masuda Yukari, Mehrazad Saber Zahra, Karkoutly Samia, Tao Duhan, Ye Chen, Mendsaikhan Tsolmon, Saikawa Rika, Kondo Yasuyuki, Murayama Yuki, Shikama Akito, Matsuzaka Takashi, Shimano Hitoshi, Kawakami Yasushi, Yahagi Naoya

Abstract excerpt

Plasma concentration of high-density lipoprotein cholesterol (HDL-C) is among the most important risk factors for coronary artery disease and apolipoprotein A1 (APOA1) is an essential apolipoprotein that constitutes HDL. However, few comprehensive searches have been conducted to identify noncoding functional SNPs around the APOA1 gene. In this study, we report the identification of a functional SNP, rs12718466,...

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Topics

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Share to Apolipoprotein A-I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Cholesterol, HDL

Share to Gene Expression Regulation

Share to Hepatocytes

Share to Promoter Regions, Genetic

Share to Protein Binding

Share to SOXF Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42055329
DOI: 10.1016/j.jbc.2026.113101
PMCID: PMC13226946

Genes

APOA1
SOX7
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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