Article

Three rare variants of SOX7 impairing its interaction with GATA4 may be a predisposing factor to complete AVSD

2020-05-28

Abstract excerpt

<title>Abstract</title> <p>Background Atrioventricular septal defects (AVSD) are a complicated subtype of congenital heart defects for which the genetic basis is poorly understood. Many evidences have demonstrated that transcription factor SOX7 which can interact with GATA4 plays a pivotal role in the cardiovascular development. The critical role of GATA4 in the morphogenesis of atrioventricular septum implies SO...

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Literature Corpus work: 1662d784-2baf-531b-84ce-c4f59defe48d
DOI: 10.21203/rs.3.rs-30638/v1

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