Article
erbB3 is an active tyrosine kinase capable of homo- and heterointeractions.
Molecular and cellular biology - 1 Mar 2014
Steinkamp Mara P, Low-Nam Shalini T, Yang Shujie, Lidke Keith A, Lidke Diane S, Wilson Bridget S
Abstract excerpt
Often considered to be a "dead" kinase, erbB3 is implicated in escape from erbB-targeted cancer therapies. Here, heregulin stimulation is shown to markedly upregulate kinase activity in erbB3 immunoprecipitates. Intact, activated erbB3 phosphorylates tyrosine sites in an exogenous peptide substrate, and this activity is abolished by mutagenesis of lysine 723 in the catalytic domain. Enhanced erbB3 kinase activity...
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