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Article

The causal relationship between polycystic ovary syndrome and structural changes in brain: a Mendelian randomization study.

Brain imaging and behavior - 29 Apr 2026

Yang Han, Xie Wei, Galvis Camilo Alberto Pinzon, Huang Si, He Xu, Yu Si-Yi, You Qing, Liang Fan-Rong, Xiao Zhi-Yong, Li Ning

Abstract excerpt

The impact of sex hormones on the brain has been widely recognized. Polycystic ovary syndrome (PCOS) is frequently accompanied by abnormal hormone. Furthermore, psychiatric disorders are among the most common comorbidities associated with PCOS. However, whether PCOS induces alterations in brain structure remains unclear. Mendelian randomization (MR) was conducted to determine this causal association and pinpoint...

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PMID: 42053686
DOI: 10.1007/s11682-026-01143-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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