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Article

Causal Effects of Genetically Determined Metabolites on Risk of Polycystic Ovary Syndrome: A Mendelian Randomization Study.

Frontiers in endocrinology - 1 Jan 2020

Sun Shuliu, Jiao Minjie, Han Chengcheng, Zhang Qian, Shi Wenhao, Shi Juanzi, Li Xiaojuan

Abstract excerpt

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that is influenced by both genetic and environmental factors. However, the etiology of PCOS remains unclear. Methods: We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal effects of genetically determined metabolites (GDMs) on the risk of PCOS. We used summary level data of a genome-wide association...

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Databases, Genetic
Genome-Wide Association Study
Genotype
Mendelian Randomization Analysis
Ovarian cancer diagnosis and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian function and disorders

Polycystic Ovary Syndrome

Polymorphism, Single Nucleotide

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Identifiers

PMID: 33013699
DOI: 10.3389/fendo.2020.00621
PMCID: PMC7505923

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