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Mendelian Randomization Analyses Reveal Causal Relationships between Brain Structural Connectivity and Risk of Polycystic Ovary Syndrome.

Gynecologic and obstetric investigation - 1 Jan 2026

Niu Huimin, Xia Lian, Zhang Xinyi, Lin Chuning, Ge Yao, Chen Yuan, Sun Feng, Jiang Feng, Wu Chuyan

Abstract excerpt

OBJECTIVES: To explore the relationship between brain structural connectivity and polycystic ovary syndrome (PCOS). DESIGN: Two-sample Mendelian randomization (2SMR) was conducted by querying a relevant European population genome-wide association studies (GWAS) database about the anatomical connections of the brain and polycystic ovarian syndrome from the Ieu Open GWAS Project database. Two hundred six brain...

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PMID: 40403712
DOI: 10.1159/000546487

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