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Article

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues.

Cell reports - 16 Nov 2021

D'Antonio Matteo, Nguyen Jennifer P, Arthur Timothy D, Matsui Hiroko, D'Antonio-Chronowska Agnieszka, Frazer Kelly A

Abstract excerpt

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression...

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Identifiers

PMID: 34762851
DOI: 10.1016/j.celrep.2021.110020
PMCID: PMC8563343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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