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Article

Water-mediated compensation preserves WIN motif binding in WDR5 aromatic mutants.

Biochemical and biophysical research communications - 25 Jun 2026

Pan Yan, Li Hao, Peng Shan, Wang Haoran, Wu Zhangyu, Hang Tianrong, Liu Yongrui, Yang Yang

Abstract excerpt

WD repeat-containing protein 5 (WDR5) recognizes canonical arginine-containing WDR5-interacting (WIN) motifs through a highly conserved binding pocket, in which WDR5 Phe133 and Phe263 are thought to stabilize the central arginine via cation-π interactions. Here, we re-evaluate the contribution of these residues using the MBD3C WIN peptide, which exhibits dual-site engagement with the WIN and B pockets. Isothermal...

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Identifiers

PMID: 42048953
DOI: 10.1016/j.bbrc.2026.153842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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