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Article

Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5.

Molecular cell - 7 Apr 2006

Han Zhifu, Guo Lan, Wang Huayi, Shen Yue, Deng Xing Wang, Chai Jijie

Abstract excerpt

The WD40 repeat protein WDR5 specifically associates with the K4-methylated histone H3 in human cells. To investigate the structural basis for this specific recognition, we have determined the structure of WDR5 in complex with a dimethylated H3-K4 peptide at 1.9 A resolution. Unlike the chromodom...

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Share to Crystallography, X-Ray
Share to Heterotrimeric GTP-Binding Proteins
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16600877
DOI: 10.1016/j.molcel.2006.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16600877-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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