Article
Polypentagonal ice-like water networks emerge solely in an activity-improved variant of ice-binding protein.
Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018
Mahatabuddin Sheikh, Fukami Daichi, Arai Tatsuya, Nishimiya Yoshiyuki, Shimizu Rumi, Shibazaki Chie, Kondo Hidemasa, Adachi Motoyasu, Tsuda Sakae
Abstract excerpt
Polypentagonal water networks were recently observed in a protein capable of binding to ice crystals, or ice-binding protein (IBP). To examine such water networks and clarify their role in ice-binding, we determined X-ray crystal structures of a 65-residue defective isoform of a Zoarcidae-derived IBP (wild type, WT) and its five single mutants (A20L, A20G, A20T, A20V, and A20I). Polypentagonal water networks...
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