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Article

Effect of the Flexible Regions of the Oncoprotein Mouse Double Minute X on Inhibitor Binding Affinity.

Biochemistry - 7 Nov 2017

Qin Lingyun, Liu Huili, Chen Rong, Zhou Jingjing, Cheng Xiyao, Chen Yao, Huang Yongqi, Su Zhengding

Abstract excerpt

The oncoprotein MdmX (mouse double minute X) is highly homologous to Mdm2 (mouse double minute 2) in terms of their amino acid sequences and three-dimensional conformations, but Mdm2 inhibitors exhibit very weak affinity for MdmX, providing an excellent model for exploring how protein conformation distinguishes and alters inhibitor binding. The intrinsic conformation flexibility of proteins plays pivotal roles in...

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PMID: 29023092
DOI: 10.1021/acs.biochem.7b00903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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