Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unusual Case of Neuromeningeal Late Relapse of POLE Mutated Endometrioid Carcinoma: A Case Report and Systematic Review.

Current oncology (Toronto, Ont.) - 16 Apr 2026

Donati Emma, Fabbro Michel, Drappier Noémie, Marguerit Alexis, Leaha Cristina, Nougaret Stéphanie, Colombo Pierre-Emmanuel, Quesada Stanislas

Abstract excerpt

Background: POLE-mutated endometrial carcinomas are associated with exceptionally favorable outcomes, forming the basis for treatment de-escalation in early-stage disease. Nevertheless, rare adverse clinical courses have been reported. This study describes an unusual case of late metastatic recurrence in a POLE-mutated tumor and provides a review of similar cases in the literature. Methods: We present a detailed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Endometrioid
Share to DNA Polymerase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to POLE gene

Share to Meningeal Neoplasms

Share to Mutation

Share to Neoplasm Recurrence, Local

Share to Poly-ADP-Ribose Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42041738
DOI: 10.3390/curroncol33040219
PMCID: PMC13114587

Genes

POLE
PTEN
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unusual Case of Neuromeningeal Late Relapse of POLE Mutated Endometrioid Carcinoma: A Case Report and Systematic Review.PMID 42041738Read ↗

The relationship between histopathological data and molecular alterations with oncological outcomes in endometrioid-type endometrial cancers and a novel POLE mutation.Semantic proximity Read ↗

The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive ReviewSemantic proximity Read ↗

Molecular classification of metastatic and recurrent endometrial endometrioid carcinoma: prognostic relevance among low- and high-stage tumours.Semantic proximity Read ↗

Genetic predictors of unexpected recurrence in low-risk endometrial cancer: A comprehensive genomic analysis reveals FGFR2 as a risk factor and a rare fatal POLE-mutated recurrence.Semantic proximity Read ↗

Clonal Progression of a DNA Polymerase Epsilon-Mutant Endometrial Cancer With Immune Evasion Characteristics and Metastasis.Semantic proximity Read ↗

Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study.Semantic proximity Read ↗

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.Semantic proximity Read ↗

Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.Semantic proximity Read ↗

Pelvic Carcinosarcoma Showing a Diverse Histology and Hierarchical Gene Mutation with a Common POLE Mutation to Endometrial Endometroid Carcinoma: A Case Report.Semantic proximity Read ↗

The clinicopathological characteristics of POLE-mutated/ultramutated endometrial carcinoma and prognostic value of POLE status: a meta-analysis based on 49 articles incorporating 12,120 patients.Semantic proximity Read ↗

Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer.Semantic proximity Read ↗

Prognostic significance of POLE proofreading mutations in endometrial cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.