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Article

Clonal Progression of a DNA Polymerase Epsilon-Mutant Endometrial Cancer With Immune Evasion Characteristics and Metastasis.

Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2026

Fan Ruirui, Gao Jie

Abstract excerpt

Renal transplant recipients are at significantly higher risk of developing malignancies because of chronic immunosuppression. Although DNA polymerase epsilon (POLE)-mutated endometrioid carcinoma (EC) typically presents as early-stage disease with an excellent prognosis and rare metastasis, we conducted a study on POLE-mutated EC in a transplant recipient that rapidly progressed and metastasized. We aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41571190
DOI: 10.1016/j.labinv.2026.106074

Genes

POLE
PIK3CD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Clonal Progression of a DNA Polymerase Epsilon-Mutant Endometrial Cancer With Immune Evasion Characteristics and Metastasis.PMID 41571190Read ↗

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