Article
Pelvic Carcinosarcoma Showing a Diverse Histology and Hierarchical Gene Mutation with a Common POLE Mutation to Endometrial Endometroid Carcinoma: A Case Report.
International journal of surgical pathology - 1 Dec 2022
Kitazono Ikumi, Akahane Toshiaki, Kobayashi Yusuke, Yanazume Shintaro, Tabata Kazuhiro, Tasaki Takashi, Noguchi Hirotsugu, Kirishima Mari, Higashi Michiyo, Kobayashi Hiroaki, Tanimoto Akihide
Abstract excerpt
POLE mutation-type endometrial cancer is characterized by an extremely high tumor mutation burden. Most POLE mutation-type endometrial cancers are histologically endometrioid carcinomas, and POLE mutation-type carcinosarcomas are rare among endometrial cancers. We report a case of endometrial and pelvic cancer in a 53-year-old woman who was analyzed using next-generating sequencing. The endometrial lesion...
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