Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mutational and transcriptional status of RYR in CRC and its indication for prognosis.

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology - 1 May 2026

Hu Jiangping, Peng Minxuan, Ou Qi, Zhou Yi

Abstract excerpt

Aberrant calcium signaling, particularly the ryanodine receptor (RYR) signaling, is linked to cancer development. Currently, little is known about the status of RYR in colorectal cancer (CRC), and the correlation of RYR with CRC phenotypes remains unclear. We analyzed genetic alterations in RYRs using data from 587 patients with CRC in the TCGA database. Mutations were spread across RYR channels without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasm Staging
Share to Age Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Mutation

Share to Prognosis

Share to Ryanodine Receptor Calcium Release Channel

Share to Transcription, Genetic

Source

Identifiers

PMID: 42031610
DOI: 10.1016/j.ajg.2026.03.002

Genes

RYR2
RYR1
RYR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mutational and transcriptional status of RYR in CRC and its indication for prognosis.PMID 42031610Read ↗

The ryanodine receptor mutational characteristics and its indication for cancer prognosis.Semantic proximity Read ↗

Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic UtilitySemantic proximity Read ↗

Association of RYR2 Mutation With Tumor Mutation Burden, Prognosis, and Antitumor Immunity in Patients With Esophageal AdenocarcinomaSemantic proximity Read ↗

Association of RYR2 Mutation with Tumor Mutation Burden, Prognosis and Antitumor Immunity in Patients with Esophageal AdenocarcinomaSemantic proximity Read ↗

Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes.Semantic proximity Read ↗

The Role of Ryanodine Receptor 2 Polymorphisms in Oral Squamous Cell Carcinoma Susceptibility and Clinicopathological Features.Semantic proximity Read ↗

Interactomic exploration of LRRC8A in volume-regulated anion channelsSemantic proximity Read ↗

Ryanodine Receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypesSemantic proximity Read ↗

Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesisSemantic proximity Read ↗

Evolution of Vertebrate Ryanodine Receptors Family in Relation to Functional Divergence and Conservation.Semantic proximity Read ↗

Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3.Semantic proximity Read ↗

Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3β Signaling Pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.