Article
The ryanodine receptor mutational characteristics and its indication for cancer prognosis.
Scientific reports - 27 Sept 2022
Wang Fenglin, Yu Jingbo, Lin Ping, Sigalas Charalampos, Zhang Shibo, Gong Yuan, Sitsapesan Rebecca, Song Lele
Abstract excerpt
Ca2+ signaling is altered substantially in many cancers. The ryanodine receptors (RYRs) are among the key ion channels in Ca2+ signaling. This study aimed to establish the mutational profile of RYR in cancers and investigate the correlation between RYR alterations and cancer phenotypes. The somatic mutation and clinical data of 11,000 cancer patients across 33 cancer types was downloaded from The Cancer Genome...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.