Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3.

doi:10.1093/carcin/bgt344

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Article

Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3.

Carcinogenesis - 1 Feb 2014

Yang Rongxi, Chen Bowang, Pfütze Katrin, Buch Stephan, Steinke Verena, Holinski-Feder Elke, Stöcker Sarah, von Schönfels Witigo, Becker Thomas, Schackert Hans K, Royer-Pokora Brigitte, Kloor Matthias, Schmiegel Wolff H, Büttner Reinhard, Engel Christoph, Lascorz Puertolas Jesus, Försti Asta, Kunkel Nelli, Bugert Peter, Schreiber Stefan, Krawczak Michael, Schafmayer Clemens, Propping Peter, Hampe Jochen, Hemminki Kari, Burwinkel Barbara

Abstract excerpt

Colorectal cancer (CRC) is one of the most common cancer worldwide. However, a large number of genetic risk factors involved in CRC have not been understood. Copy number variations (CNVs) might partly contribute to the 'missing heritability' of CRC. An increased overall burden of CNV has been identified in several complex diseases, whereas the association between the overall CNV burden and CRC risk is largely...

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PMID: 24127187
DOI: 10.1093/carcin/bgt344

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