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Article

Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes.

Journal of experimental & clinical cancer research : CR - 11 Aug 2022

Zhang Li, Au-Yeung Chi-Lam, Huang Chunxian, Yeung Tsz-Lun, Ferri-Borgogno Sammy, Lawson Barrett C, Kwan Suet-Ying, Yin Zheng, Wong Stephen T, Thomas Vienna, Lu Karen H, Yip Kay-Pong, Sham James S K, Mok Samuel C

Abstract excerpt

BACKGROUND: Uterine serous cancer (USC) is the most common non-endometrioid subtype of uterine cancer, and is also the most aggressive. Most patients will die of progressively chemotherapy-resistant disease, and the development of new therapies that can target USC remains a major unmet clinical need. This study sought to determine the molecular mechanism by which a novel unfavorable prognostic biomarker ryanodine...

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Share to Cystadenocarcinoma, Serous
Share to PGC gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

Share to Ryanodine Receptor Calcium Release Channel

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Source

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Identifiers

PMID: 35953818
DOI: 10.1186/s13046-022-02419-w
PMCID: PMC9373370

Genes

RYR1
HK1
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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