Article
Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study.
JNCI cancer spectrum - 3 Nov 2025
Chalitsios Christos V, Markozannes Georgios, Aglago Elom K, Berndt Sonja I, Buchanan Daniel D, Campbell Peter T, Cao Yin, Chan Andrew T, Dimou Niki, Drew David A, French Amy J, Georgeson Peter, Giannakis Marios, Gruber Stephen B, Gunter Marc J, Harrison Tabitha A, Hoffmeister Michael, Hsu Li, Huang Wen-Yi, Hullar Meredith A J, Huyghe Jeroen R, Lynch Brigid M, Moreno Victor, Murphy Neil, Newton Christina C, Nowak Jonathan A, Obón-Santacana Mireia, Ogino Shuji, Qu Conghui, Schmit Stephanie L, Steinfelder Robert S, Sun Wei, Thomas Claire E, Toland Amanda E, Trinh Quang M, Ugai Tomotaka, Um Caroline Y, Guelpen Bethany Van, Zaidi Syed H, Schoen Robert E, Woods Michael O, Brenner Hermann, Andreson Laura, Pellatt Andrew J, Peters Ulrike, Phipps Amanda I, Tsilidis Konstantinos K
Abstract excerpt
BACKGROUND: Physical activity is associated with lower colorectal cancer (CRC) risk, but its association with molecular subtypes defined by genetic and epigenetic alterations of the disease is unclear. Such information may enhance the understanding of the mechanisms related to the benefits of physical activity. METHODS: Pooled observational (cases: n = 5386; controls: n = 6798; studies n = 5) and genome-wide...
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