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Article

Remnant Cholesterol and Incident Depression in Aging: A 14-Year Prospective Cohort Study and Mendelian Randomization Analysis.

Psychiatry research - 1 Jul 2026

Qi Mengmeng, Wang Mengmeng, Li Yonghao, Cai Xiaoxiao

Abstract excerpt

BACKGROUND: Long-term cohort data combined with Mendelian randomization (MR) were used to investigate whether elevated remnant cholesterol (RC) causally contributes to depression risk. METHODS: A total of 4,422 adults aged ≥50 years from Wave 2 (2004-2005) of the ELSA were followed up to 14 years through Wave 9 (2019). Incident depression was defined as CES-D ≥4 during follow-up. Associations were assessed using...

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PMID: 42030924
DOI: 10.1016/j.psychres.2026.117170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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