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Article

Omega-3 fatty acids and major depression: a Mendelian randomization study.

Translational psychiatry - 29 May 2024

Carnegie R, Borges M C, Jones H J, Zheng J, Haycock P, Evans J, Martin R M

Abstract excerpt

Omega-3 fatty acids have been implicated in the aetiology of depressive disorders, though trials supplementing omega-3 to prevent major depressive disorder (MDD) have so far been unsuccessful. Whether this association is causal remains unclear. We used two sample Mendelian randomization (MR) to investigate causality. Genetic variants associated with circulating omega-3 and omega-6 fatty acids in UK Biobank (UKBB,...

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PMID: 38811538
DOI: 10.1038/s41398-024-02932-w
PMCID: PMC11136966

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