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Heartache and Heartbreak: An Observational and Mendelian Randomization Study.

Global heart - 1 Jan 2024

Cai Dihui, Xia Mengming, Chen Xuhui, Yagi Kunimasa, Xu Liang, Wang Bingyu, Wang Yanyi, Zhou Yujie, Liu Jianhui

Abstract excerpt

Background: Depression has a significant effect on cardiovascular disease (CVD), but uncertainties persist regarding which modifiable risk factors mediate the causal effects. We aim to determine whether depression is causally linked to CVD and which modifiable risk factors play potential mediating roles. Methods: We used a two-sample Mendelian randomization (MR) approach and NHANES 2007-2018 data to estimate the...

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Identifiers

PMID: 38371655
DOI: 10.5334/gh.1302
PMCID: PMC10870952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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